GlaxoSmithKline, Inc. and Ometric Corporation have jointly approved the release of the following partial abstract of a paper to be published.
Real-Time Monitoring of Pharmaceutical Powder Blending at Low Concentrations Using Multivariate Optical Computing
Dwight S. Walker1, Robert P. Freese2,
David L. Perkins2, Ryan J. Priore2, Kwabena
Amponsah-Manager1, John C. Blackburn2, and Jonathan H.
James2
1 - GlaxoSmithKline Inc., Research Triangle Park, NC
2 - Ometric Corporation., Columbia, SC
Abstract
Near-infrared (NIR) spectroscopy of a pharmaceutical
powder containing two active ingredients in an excipient was used as the basis
for the design of a multivariate optical computing system. Dynamic blending
experiments in a Key pharmaceutical blender in which the active was added were
recorded. Dynamic experiments yielded a blending time-to-homogeneity of 20
minutes.
